A new, simple and rapid spectrophotometric method with broad linear dynamic range was developed for the quantification of two angiotensin- converting enzyme inhibitors, namely cilazapril and alacepril. The method was based on the oxidation of the two drugs by Fe(III) in presence of 1.10 phenanthroline, the formed tris-(Fe-o-phen) complex in acetate buffer and optimum pH was measured at λmax 510 and 512 nm for cilazapril and alacepril respectively with linear relationship over concentration…

Cancer is a genetically driven disease characterized by the progressive accumulation of somatic mutations, chromosomal aberrations, epigenetic dysregulation, and transcriptional reprogramming that collectively promote malignant transformation and immune escape. This genomic instability generates profound tumour heterogeneity, driving therapeutic resistance, immune evasion, and disease relapse. These challenges have accelerated the development of precision immunotherapies, such as chimeric…

Currently, meadow feed production pays special attention to the creation and use of legumes and legume-grain herbages that provide cheap and high-quality feed [1, 2]. However, the soil and climatic conditions of both the North-Western region and the Leningrad Region do not allow for the widespread placement and creation of legume and cereal stands, therefore, cereal stands remain the main segment in the wedge of perennial grasses, which are characterized by a high rate of passage of…

Measles Virus (MV), despite being well controlled with vaccination, is making a resurgence due to the loss of herd immunity from a decreased rate of vaccination. There are many reasons for the decreased vaccination rate, especially in high income countries. This review will discuss the MV epidemiology, pathophysiology, immunologic response of the host and MV dodging of immune host response, risk factors for MV infection, diagnosis, differential diagnosis, complications, treatment,…

Chronic stroke patients experience persistent upper limb impairments that limit hand function resulting in reduced quality of life and overall independence in ADLs. Soft robotic hand gloves may improve hand Range Of Motion (ROM) by promoting motor learning and neuroplasticity. A descriptive-correlational pre-test and post-test study was used in this study. The participants were composed of 20 chronic stroke patients aged 55-65 years from Metro Manila - selected through a purposive sampling…

Huanglongbing (HLB), also known as citrus greening, is currently one of the most destructive diseases threatening citrus production worldwide, having been reported globally. The disease is associated with the phloem-limited, vector-transmitted bacterium Candidatus Liberibacter asiaticus, and its management is strongly dependent on early and reliable diagnosis. However, symptom development is often slow and nonspecific, frequently overlapping with nutritional disorders and abiotic stress.…

Inguinal hernia remains one of the most frequent surgical conditions in preterm infants. While early repair has traditionally been advocated to prevent incarceration, emerging evidence suggests that delayed intervention may allow for spontaneous resolution in select cases. This review synthesizes updated systematic reviews and meta-analyses, incorporating Trial Sequential Analysis (TSA), to evaluate the balance between early versus late repair. Particular attention is given to the role of…

Background: Labour induction is increasingly common, and misoprostol is widely used due to its efficacy, affordability, and stability. The optimal administration route remains debated, particularly regarding efficacy and safety.

Objective: To compare the efficacy and safety of low-dose oral versus vaginal misoprostol for labor induction and evaluate associated maternal and neonatal outcomes.

Methods: Pregnant women…

Background: Female reproductive hormones exert systemic effects extending beyond reproductive physiology to influence hematopoiesis, immune regulation, endothelial integrity, and haemostatic balance. Cyclical and life‑stage hormonal variations significantly alter haematological and coagulation parameters.

Objective: To systematically review and synthesize evidence on the association between female reproductive hormones and haematological and…

Background: Severe malaria remains a leading cause of morbidity and mortality worldwide, particularly among vulnerable populations such as the elderly and individuals with comorbidities. The interaction between malaria, dehydration, hypertension, and stroke can accelerate multiorgan dysfunction through complex hematological, haemostatic, and microvascular mechanisms.

Case Presentation: We report the case of an 85-year-old hypertensive female with…