Prolonged Incubation with Glucose Induces Oligomerization and Aggregation of Hemoglobin: Role of Advanced Glycation End Product on Protein Structure
Non-enzymatic glycation is a post-translational modification of proteins that leads to protein crosslinking, aggregation, conformational changes, etc. Chemical reaction of sugars with proteins (Maillard reaction) leads to formation of glycated adducts, known as Advanced Glycation End Products…...
10.5281/zenodo.20139601