K. Gorgi ^{1 *} M. Chaouche ² K. Rifai ¹ H. Iraqi ¹ M.H. Gharbi ¹

Wolfram Syndrome (WS), also known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), is a rare neurodegenerative disorder [1, 2]. This condition features symptoms that typically appear progressively from childhood through adulthood [3, 4, 5]. Diagnosis is based on specific clinical criteria and confirmed by genetic testing for mutations in the WFS1 gene [6, 7]. Insulin therapy remains the mainstay treatment for diabetes mellitus, but incretin analogs may provide…

Amparo Leticia de la Fuente-Reynoso ^{1 *} Jennifer Dyall ¹ Laura Verónica Peña-Zermeño ¹ Agostino Menna ¹ Tom Adamyk ¹

Objective: The objective of this case study is to examine the effects of a structured Clinical Pilates (CP) intervention on functional mobility, balance, disability, quality of life, and selected biochemical markers in a 69-year-old male patient diagnosed with Idiopathic Inflammatory Myositis (IIM). Limited evidence regarding CP’s potential to improve functional mobility, balance, and psychosocial well-being in this population underscores the urgent need for exploratory,…

Zaparackaite I ¹ Govani ND ² Singh H ³ Singh SJ ⁴ Mehta AR ⁵ Midha PK ⁵ Patel R ² Patel RV ^{2 *}

Objectives: To synthesise current evidence on modified and extended anorectal myomectomy and transanal endosurgical procedures as diagnostic and therapeutic tools in congenital and acquired colorectal motility disordersand to clarify their role alongside manometry, radiology, and histopathology in contemporary clinical practice [1-4].

Design: Narrative review.

Data Sources: Peer-reviewed literature from PubMed,…

Govani DR ¹ Mehta AR ² Midha PK ³ Govani ND ¹ Panchasara NG ¹ Patel RR ¹ Patel RV ^{1 *}

This manuscript describes two exceptionally rare neonatal presentations of synchronous multiple neural tube defects (NTDs), involving separate thoracolumbar, lumbar, and sacral myelomeningoceles. We report two neonates presenting with synchronous dual and triple, open and closed spinal dysraphisms—distributed across thoracolumbar, lumbar, and sacral regions— without associated cranial defects. Both infants underwent early surgical repair. Case 1 demonstrated favorable early neurological…

G. Kalai Priya ^{1 *} P. Muthukrishnan ²

Background: Beedi rolling is a highly repetitive occupation characterized by prolonged static postures and forceful hand movements, making workers vulnerable to work-related musculoskeletal disorders (WRMSDs). The prevalence of musculoskeletal symptoms in beedi workers ranges from 34.6% to 87.0% across different populations.

Objective: To assess occupational ergonomic risk factors in beedi workers using the Rapid Upper Limb Assessment (RULA) and…

P.J. Ameera ^{1 *} P. Muthukrishnan ²

Background: Anterior knee pain (AKP), commonly termed patellofemoral pain syndrome, represents the most prevalent lower extremity complaint in college-aged populations, affecting approximately 25% of physically active students. While quadriceps muscle weakness has been extensively characterized in patellofemoral pain pathophysiology, the role of muscle stiffness—a distinct biomechanical property reflecting tissue resistance to deformation—remains inadequately explored.…

Gorgi K ^{1 *} Chaouche M ²

Introduction: Hungry Bone Syndrome (HBS) is a rare but potentially severe metabolic complication following parathyroidectomy, occurring mainly in patients with severe primary hyperparathyroidism (PHPT) and high bone turnover [1–3].

Case Reports: We report two cases of HBS occurring after parathyroidectomy for advanced primary hyperparathyroidism. Both patients presented with marked preoperative hypercalcemia, very high parathyroid hormone (PTH)…

Gorgi K ^{1 *} Chaouche M ²

Introduction Maturity Onset Diabetes of the Young (MODY) is a heterogeneous group of monogenic diabetes characterized by a primary defect in insulin secretion. It is a rare form of diabetes caused by autosomal dominant mutations, usually non-autoimmune and non-ketotic [1, 2]. The diagnosis of MODY is often overlooked in resource-limited countries, notably due to the frequent unavailability of genetic testing [3].

This study reports a series of 12 suspected MODY diabetes cases…

Nourhan Alsaeeid Alsaeeid ^{1 *} Hanaa Mohamed Ibrahim ² Shymaa Ali Abdel Ati ¹ Marwa Tantawy ³ Abubakr Khalil Elshazly ³ Nada Haytham ¹ Rwayda Ahmed ¹ Dina Safwat Elasall ⁴

Median nerve injuries in pediatric patients represent a significant challenge due to their impact on hand function and fine motor development. This case report presents the rehabilitation outcomes of a seven-year-old child who sustained a traumatic injury involving the flexor pollicislongus and flexor carpi radialis muscles with associated radial artery injury and median nerve lesion. The patient underwent a structured physiotherapy program including neuromuscular electrical stimulation and…

Gorgi K ^{1 *} Chaouche M ²

Latent autoimmune diabetes in adults (LADA) is an autoimmune form of diabetes situated between classical type 1 diabetes (T1D) and type 2 diabetes (T2D). It typically affects older adults and progresses more slowly toward insulin dependence. We report three cases of elderly female patients presenting with inaugural diabetic ketosis revealing slowly progressive type 1 diabetes. These observations highlight the diagnostic challenges and clinical features of this still poorly understood entity…