Background: Medial tibial stress syndrome (MTSS) affects 4-35% of runners with substantial recurrence rates ranging from 25-57% following standard care protocols. While individual interventions (load management, gait retraining, strengthening) demonstrate independent efficacy, high-quality randomized controlled trial evidence evaluating integrated models combining all three components remains limited in the current literature.

Objective: To…

Background: While gait retraining and neuromuscular strengthening demonstrate individual clinical efficacy in medial tibial stress syndrome (MTSS) management, the integrated biomechanical mechanisms through which combined intervention modifies lower limb loading parameters and tissue stress remains inadequately characterized in contemporary literature. High-resolution biomechanical quantification integrating three-dimensional motion capture, ground reaction force analysis,…

Introduction: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders, characterized by inappropriate secretion of parathyroid hormone (PTH), leading to disturbances in calcium–phosphate metabolism and multisystem complications.

Objective: To determine the prevalence and profile of clinical, biological, and radiological complications of PHPT in a Moroccan hospital-based cohort.

Materials and…

Introduction: Celiac disease (CD) is an autoimmune enteropathy triggered by gluten ingestion in genetically predisposed individuals. It is frequently associated with type 1 diabetes (T1D), with a prevalence significantly higher than that observed in the general population. Diagnosis usually relies on positivity of specific autoantibodies and histological confirmation. However, seronegative forms can be observed, notably in T1D patients, making diagnosis more…

Introduction: Graves’ disease is an autoimmune disorder characterized by hyperthyroidism related to the presence of thyroid-stimulating hormone receptor antibodies. Long considered protective against thyroid cancer, it is now recognized as potentially associated with differentiated thyroid carcinomas, mainly papillary carcinoma.

Objective: To describe the clinical, histological, therapeutic, and outcome characteristics of thyroid carcinomas…

Background: Patient–ventilator asynchrony (PVA) is a common complication in mechanically ventilated patients, leading to increased morbidity, prolonged ventilation, and respiratory muscle fatigue. Early detection is critical. Artificial intelligence (AI) systems, including convolutional neural networks (CNNs) and machine learning algorithms, have been applied to automate detection.

Objective: To systematically review current evidence on AI-based…

Objectives: To re‑examine infantile hypertrophic pyloric stenosis (IHPS) through a contemporary, multidimensional framework that integrates structural, functional, and psycho‑neuro‑endocrine‑immune (PNEI) mechanisms. This review synthesises current evidence on IHPS epidemiology, pathophysiology, and clinical presentation, and evaluates minimally invasive diagnostic and therapeutic approaches. It further explores how emerging insights into gut–brain and neuroimmune regulation…

A six‑year‑old girl presented with a left‑sided abdominal mass and a non‑functioning left kidney, initially diagnosed radiologically as Wilms’ tumor. Intraoperatively, the kidney was found to be compressed—not invaded—by a massive, benign‑appearing retroperitoneal tumor. The mass was excised with preservation of the kidney. Unrecognised extension of the tumor through the lumbar intervertebral foramen resulted in a postoperative spinal epidural hematoma, causing acute paraparesis. Emergency…

Turner syndrome (TS) is a rare chromosomal disorder characterized by partial or complete monosomy X. The presence of Y chromosome material, particularly the sex-determining region Y(SRY) gene, has important clinical implications due to the increased risk of gonadoblastoma. We report two cases of young women with Turner syndrome harboring Y chromosome material detected by fluorescence in situ hybridization (FISH), illustrating the phenotypic variability, diagnostic challenges, and therapeutic…

Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by inappropriate parathyroid hormone (PTH) secretion leading to chronic hypercalcemia. Acute pancreatitis is a rare but potentially severe complication of PHPT. We report three cases in which acute pancreatitis was the revealing manifestation of primary hyperparathyroidism. These observations emphasize the importance of systematically investigating metabolic causes, particularly hypercalcemia, in cases of acute…