ARTICLE TYPE : CASE REPORT
Published on : 31 Jan 2026, Volume - 2
Journal Title : WebLog Journal of Oncology | WebLog J Oncol
Source URL: 
https://weblogoa.com/articles/wjo.2026.a3102
Permanent Identifier (DOI) : 
https://doi.org/10.5281/zenodo.18497845
Familial Metachronous Wilms’ Tumour in a Sibling with Previous Bilateral Synchronous Wilms’ Tumour: A Rare Familial Cluster
2Formerly Head, Department of Surgery at Tata Memorial Hospital, Mumbai, India
3J. Watumull Global Hospital & Research Centre, Delwara Road, Mount Abu, Rajasthan 307501, India Affiliated to Medical Faculty of God Fatherly Spiritual University, Mount Abu, Rajasthan, India
Abstract
Wilms Tumour (WT) is the most common renal malignancy of childhood, typically occurring sporadically. Familial WT accounts for fewer than 2% of cases and often involves germline predisposition syndromes. Metachronous WT in siblings - particularly when one sibling previously presented with bilateral synchronous disease - is exceptionally rare. We report a case of a child presenting with unilateral WT whose older sibling had been treated several years earlier for bilateral synchronous WT. This case highlights the importance of familial risk assessment, genetic counselling, structured surveillance, and early detection strategies in families with suspected hereditary WT predisposition.
Keywords: Wilms Tumour; Familial Wilms Tumour; Bilateral Synchronous Wilms Tumour; Metachronous Tumour; Nephrogenic Rests; Hereditary Cancer Predisposition; Paediatric Renal Tumour; Genetic Counselling; Nephron‑Sparing Surgery; Childhood Cancer Surveillance
Citation
Govani DR, Mehta AR, Midha PK, Govani ND, Panchasara NG, Patel R, et al. Familial Metachronous Wilms’ Tumour in a Sibling with Previous Bilateral Synchronous Wilms’ Tumour: A Rare Familial Cluster. WebLog J Oncol. wjo.2026.a3102. https://doi.org/10.5281/zenodo.18497845