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ARTICLE TYPE : RESEARCH ARTICLE

Published on :   29 Nov 2025, Volume - 1
Journal Title :   WebLog Journal of Neurology | WebLog J Neurol
Source URL:   weblog iconhttps://weblogoa.com/articles/wjn.2025.k2901
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.17845810

Exploring the Incidence of Cognitive Dysfunction and Sleep Disorders in Charcot-Marie-Tooth

Shivani Waghmare 1
Soha Mohammad 1
Ronak Bhatia 1
Elizabeth Beyene 2
Syed Fahad Gillani 2
Jeffrey Palmer 1
Mekdem Bisrat 2 *
Samrawit Zinabu 2
Miriam Michael 2
Ahmed Ali 2
1Department of Neurology, Howard University Hospital, Washington DC, USA
2Department of Internal Medicine, Howard University Hospital, Washington DC, USA

Abstract

Background: Charcot-Marie-Tooth disease (CMT) is a genetically heterogeneous peripheral neuropathy traditionally considered to spare the central nervous system (CNS). However, recent reports suggest possible CNS involvement, including cognitive impairment and sleep disturbances. The true prevalence of these manifestations remains unclear due to limited large-scale data.

Methods: We conducted a retrospective cohort study using data from 141 healthcare organizations within the Global Collaborative Network. Patients aged ≤50 years with a diagnosis of hereditary motor and sensory neuropathy (ICD-10: G60.0) were included. Exclusion criteria comprised conditions that independently contribute to cognitive or sleep disorders. Diagnoses of cognitive impairment and sleep disorders were identified using standardized ICD-10 codes.

Results: Among 11,795 patients, 466 (3.95%) were diagnosed with cognitive impairment and 791 (6.71%) with sleep disorders. Cognitive impairment was more common in females (4.34%) than males (3.56%), with peak incidence in the 25–29 age group (6.2%). Sleep disorders also showed higher prevalence in females (7.51%) versus males (5.91%), peaking similarly in the 25–29 age group (11.9%). Striking racial disparities were noted: Native Hawaiian/Pacific Islander and American Indian/Alaska Native patients had the highest prevalence of both conditions (41.7% and 25.6%, respectively). These patterns suggest underrecognized CNS involvement in CMT across diverse subgroups.

Conclusion: Cognitive dysfunction and sleep disorders occur at clinically significant rates in patients with CMT, particularly among younger adults and racially minoritized populations. These findings highlight the need for expanded clinical screening and further mechanistic studies to understand CNS involvement in CMT.

Keywords: Charcot-Marie-Tooth; Cognitive Dysfunction; Sleep Disorder

Citation

Waghmare S, Mohammad S, Bhatia R, Beyene E, Fahad Gillani S, Palmer J, et al. Exploring the Incidence of Cognitive Dysfunction and Sleep Disorders in Charcot-Marie-Tooth. WebLog J Neurol. wjn.2025.k2901. https://doi.org/10.5281/zenodo.17845810
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