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ARTICLE TYPE : CASE SERIES

Published on :   15 Jan 2026, Volume - 2
Journal Title :   WebLog Journal of Endocrinology and Diabetes | WebLog J Endocrinol Diabetes
Source URL:   weblog iconhttps://weblogoa.com/articles/wjed.2026.a1503
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.18367963

Complications of Primary Hyperparathyroidism: A Retrospective Study of 83 Cases

K. Gorgi 1 *
M. Chaouche 3
Y. Errahali 2
K. Rifai 1
H. Iraqi 1
M.H. Gharbi 1
1Department of Endocrinology, Ibn Sina University Hospital, Rabat, Morocco
2Department of Endocrinology, Mohammed V Military Hospital, Rabat, Morocco
3Department of Dermatology, Mohammed VI University Hospital, Agadir, Morocco

Abstract

Introduction: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders, characterized by inappropriate secretion of parathyroid hormone (PTH), leading to disturbances in calcium–phosphate metabolism and multisystem complications.

Objective: To determine the prevalence and profile of clinical, biological, and radiological complications of PHPT in a Moroccan hospital-based cohort.

Materials and Methods: We conducted a retrospective descriptive study including 83 patients with PHPT, followed between 2015 and 2022 in two university hospitals in Rabat. Clinical, biochemical, radiological, and bone densitometry data were analyzed.

Results: The mean age was 53.27 years (range: 11–85 years), with a marked female predominance (90.4%). Skeletal manifestations were the most frequent (56.6%), followed by digestive (15.7%), urinary (10.8%), and cardiovascular manifestations (10.8%). Skeletal complications were observed in 48.2% of patients, including fractures (14.5%) and brown tumors (9.6%). Osteoporosis was identified in 33.7% of cases.

Conclusion: Complications of PHPT remain frequent and severe, reflecting delayed diagnosis in our setting. Early detection and appropriate management could significantly reduce associated morbidity.

Keywords: Primary Hyperparathyroidism; Complications; Osteoporosis; Nephrolithiasis; Parathyroid Hormone

Citation

K. Gorgi, M. Chaouche, Y. Errahali, K. Rifai, H. Iraqi, Gharbi M.H. Complications of Primary Hyperparathyroidism: A Retrospective Study of 83 Cases. WebLog J Endocrinol Diabetes. wjed.2026.a1503. https://doi.org/10.5281/zenodo.18367963
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