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ARTICLE TYPE : CASE SERIES

Published on :   10 Jan 2026, Volume - 1
Journal Title :   WebLog Journal of Endocrinology and Diabetes | WebLog J Endocrinol Diabetes
Source URL:   weblog iconhttps://weblogoa.com/articles/wjed.2026.a1001
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.18287818

Turner Syndrome and the SRY Gene: Report of Two Cases

Gorgi K 1 *
Chaouche M 2
1Department of Endocrinology and Metabolic Diseases, Ibn Sina University Hospital, Rabat, Morocco
2Department of Dermatology, Mohammed VI University Hospital, Agadir, Morocco

Abstract

Turner syndrome (TS) is a rare chromosomal disorder characterized by partial or complete monosomy X. The presence of Y chromosome material, particularly the sex-determining region Y(SRY) gene, has important clinical implications due to the increased risk of gonadoblastoma. We report two cases of young women with Turner syndrome harboring Y chromosome material detected by fluorescence in situ hybridization (FISH), illustrating the phenotypic variability, diagnostic challenges, and therapeutic management, particularly regarding prophylactic gonadectomy.

Keywords: Turner Syndrome; SRY Gene; Y Chromosome; Gonadoblastoma; Prophylactic Gonadectomy; Disorders of Sex Development

Citation

Gorgi K, Chaouche M. Turner Syndrome and the SRY Gene: Report of Two Cases. WebLog J Endocrinol Diabetes. wjed.2026.a1001. https://doi.org/10.5281/zenodo.18287818
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