Dr. Eugene Lakem Ayuk (PhD) is a Nigerian organic and medicinal chemist, currently a Lecturer at Godfrey Okoye University, Enugu. His expertise spans organic synthesis, drug discovery/design, medicinal chemistry, nanoscience, and environmental toxicology.

• Synthetic methodology and heterocyclic chemistry
• Phytochemical analysis and biological evaluation of therapeutic compounds
• Computational docking and antimicrobial screening
• Heavy‑metal contamination and antioxidant properties of foods

• Ayuk, E. L., Igwedimma, C. C., Anosike, J. C., Oni, T. O., & Ebiem Kenechukwu, P. I. (2025). New N (7 nitro 10H phenothiazin 3 yl)benzenesulphonamide derivatives: Design, synthesis, characterization, in silico and in vitro studies on some drug resistant microorganisms. United Journal of Chemistry, 8(3), 35–51.
• Oni, T. O., & Ayuk, E. L. (2025). Synthesis of substituted arylsulphonamoyl ‘Leu Gly’ dipeptide carboxamide derivatives containing antimalarial and related pharmacological properties. Journal of Molecular Structure, 1332, 141540, 1–10. Elsevier.
• Oni, T. O., Ayuk, E. L., & Okoro, U. C. (2024). New substituted benzenesulphonamoyl ‘Cys Gly’ dipeptide carboxamide derivatives: Design, synthesis, characterization and pharmacological studies. Bioorganic Chemistry, 152, 107715. https://doi.org/10.1016/j.bioorg.2024.107715 (doi.org in Bing)
• Ayuk, E. L., Uchegbu, M. O., Ebiem Kenechukwu, P. I., & Oni, T. O. (2024). Synthesis, characterization, in silico and in vitro antimicrobial activity of phenothiazine 3 sulphonamide derivatives. Bioactivities, 2(1), 41–56. https://doi.org/10.47352/bioactivities.2963-654X.215
• Ayuk, E. L., Omeoga, P. C., Oni, T. O., & Ebiem Kenechukwu, P. I. (2024). Green synthesis of silver nanoparticles using Gongronema latifolium aqueous leaves extract and their antimicrobial and antioxidant properties. Nigeria Journal of Natural Sciences and Environmental Studies, 1(3), 96–108.
• Ayuk, E. L., Okoro, U. C., Ibeji, C. U., & Nkambule, C. M. (2023). Synthesis, in silico studies and investigations on antimicrobial, antimalarial activities of p toluenesulphonamoyl ‘Leu Gly’ dipeptide carboxamide derivatives. Journal of Molecular Structure, 1285, 135529, 1–10. Elsevier.
• Ayuk, E. L., Afoke, P. A., Aronimo, S. B., & Olowolafe, T. A. (2020). Synthesis and preliminary molecular docking studies of novel ethyl glycinate amide derivatives. International Journal of Research, 8(9), 368–382. https://doi.org/10.29121/granthaalayah.v8.i9.2020.338 (doi.org in Bing)
• Ayuk, E. L., Nwochi, S. P., Ogugor, J. C., Simon, G. I., & Ebiem Kenechukwu, P. I. (2019). Investigation of the phytochemicals and some biological parameters of Ficus sycomorus leaf extracts. IOSR Journal of Pharmacy and Biological Sciences, 14(3) II, 71–78.
• Ogugor, J. C., Ayuk, E. L., Osuji, A. S., Chikezie, C. C., & Unaegbu, M. E. (2019). Screening of phytochemicals, antimicrobial, proximate and heavy metals compositions of Pueraria phaseoloides leaf extracts. National Journal of Advanced Research, 5(2), 26–31.
• Ayuk, E. L., Eze, B., Njokunwogbu, A. N., & Aronimo, S. B. (2018). Functionalization and antimicrobial evaluation of new linear azo phenothiazine derivatives. Applied Chemistry, 1(1), 1–12.
• Ogugor, J. C., Ayuk, E. L., Osuji, A. S., Ugwu, M. O., & Unaegbu, M. E. (2018). Phytochemical, antimicrobial, proximate and heavy metals analysis of extracts of the bark of Tetrapleura tetraptera fruit. Global Scientific Journal, 6(12), 1–16.
• Ayuk, E. L., Nweke, C. M., & Ugwu, M. O. (2017). Synthesis and characterization of new complex heterocyclic ring systems of industrial importance. American Journal of Heterocyclic Chemistry, 2(1), 26–31.
• Ayuk, E. L., Oforji, C. F., Aronimo, S. B., Ugwu, F., & Njokunwogbu, A. N. (2017). Determination of secondary metabolites and biological potential of Gnetum africanum (Okazi) leaf extracts. The Pharmaceutical and Chemical Journal, 4(4), 115–122.
• Ugwu, M. O., Ayuk, E. L., & Okeke, C. C. (2017). Synthesis, spectroscopic and preliminary antimicrobial studies of some Schiff base ligands; N’N’ ethylene bis(salicylidenimine) and N,N’ bis(salicylidene) 3,5 diaminobenzoic acid and their metal complexes. International Journal of Advanced Research in Chemical Science, 4(7), 1–6. DOI: 10.20431/2349-0403.0407001.
• Ayuk, E. L., Ugwu, M. O., & Aronimo, S. B. (2017). A review on synthetic methods of nanostructured materials. Chemistry Research Journal, 2(5), 97–123.
• Ayuk, E. L., Nweke, C. M., & Agu, I. S. (2016). Synthesis and characterization of non linear 6,8 and 9,12 dichloroazaphenothiazine derivatives. Science Journal of Chemistry, 4(1), 9–13.
• Ayuk, E. L., Okoro, U. C., & Ugwu, M. O. (2016). A review on biological catalysts in organic synthesis. International Journal of Advanced Engineering Research and Applications, 2(6), 296–321.
• Ayuk, E. L., Ilo, S. U., Nweke, C. M., & Onunkwo, I. C. (2016). Palladium catalyzed synthesis and functional group modification of 6 aryl derivatives of non linear azaphenothiazones. International Journal of Chemistry and Materials Research, 4(1), 1–9.
• Engwa, G. A., Ayuk, E. L., Igbojekwe, B. U., & Unaegbu, M. (2016). Potential antioxidant activity of new tetracyclic and pentacyclic non linear phenothiazine derivatives. Biochemistry Research International, 1–9. DOI: 10.1155/2016/9896575 (dx.doi.org in Bing).
• Unaegbu, M., Engwa, G. A., Abaa, Q. D., Aliozo, S. O., Ayuk, E. L., Osuji, G. A., & Onwurah, E. I. (2016). Heavy metal, nutrient and antioxidant status of selected fruit samples sold in Enugu, Nigeria. International Journal of Food Contamination, 3, 7. DOI: 10.1186/s40550-016-0031-9 (doi.org in Bing).
• Ayuk, E. L., Okoro, U. C., & Ugwu, M. O. (2016). A review on biological catalysts in organic synthesis. International Journal of Advanced Engineering Research and Applications, 2(6), 2454–2377.
• Ayuk, E. L., Njokunwogbu, A. N., Ilo, S. U., Engwa, G. A., & Oni, T. O. (2015). Screening of phytochemicals and biological potential of aqueous, methanol and hexane extracts of Cylicodiscus gabunensis stem bark. American Journal of Biochemistry, 5(2), 30–34. DOI: 10.5923/j.ajb.20150502.02 (doi.org in Bing).
• Ayuk, E. L., Njokunwogbu, A. N., Ilo, S. U., Engwa, G. A., Oni, T. O., & Obiudu, I. K. (2015). Synthesis of new tetracyclic and hexacyclic non linear phenothiazine derivatives. International Journal of Scientific & Engineering Research, 6(4), 1988–1995.
• Ayuk, E. L., Ilo, S. U., Njokunwogbu, A. N., Engwa, G. A., Oni, T. O., & Okoro, U. C. (2015). Synthesis and characterization of 6 (4 Bromophenyl) 10 methyl 11 azabenzo[a]phenothiazine 5 one. International Journal of Materials and Chemistry, 5(2), 44–47.
• Ayuk, E. L., Njokunwogbu, A. N., Ilo, S. U., Engwa, G. A., Okoro, U. C., & Oni, T. O. (2015). Tandem catalysis of new aza angular phenothiazine ring systems. American Journal of Organic Chemistry, 5(2), 78–81.
• Ayuk, E. L., Nweke, C. M., & Agu, I. S. (2015). An efficient palladium catalyzed synthesis of non linear 6,8 diaryl diazaphenothiazinone derivatives. International Journal of Advanced Research in Chemical Sciences, 2(10), 64–71.
• Engwa, G. A., Ihekwoaba, C. J., Ilo, U. S., Unaegbu, M., Ayuk, E. L., & Osuji, G. A. (2015). Determination of some soft drink constituents and contamination by heavy metals in Nigeria. Toxicology Reports, 2, 384–390. Elsevier.

• Ayuk, E. L., Nweke, C. M., & Ugwu, M. O. (2020). Synthesis and characterization of new complex heterocyclic ring systems of industrial importance. In Ayuk, E. L. (Ed.), Prime Archives in Chemistry (1st Ed., pp. 1–7). Hyderabad, India: Vide Leaf. Available at: www.videleaf.com

• https://orcid.org/0000‑0002‑9631‑7867