Sergey V. Sennikov

M.D., Ph.D., D.Sc., Professor

Head of the laboratory of molecular Immunology,

Research Institute of fundamental and clinical Immunology, Novosibirsk, Russia

Address: Research Institute of Fundamental and Clinical Immunology (RIFCI), 630099 Novosibirsk, Russia

Email sennikov_sv@mail.ru/ sennikov@niikim.ru

Phone +7 383 222 78 08.

Education & Experience

1978-1984 Graduated from Siberian State Medical University (Tomsk, Russia) with specialty Biochemistry.

1984-1987 Completed postgraduate course in Research Institute of Fundamental and Clinical Immunology (RIFCI), Novosibirsk, Russia.

1988 Received a Ph.D. degree in Medical Sciences (specialty Allergology and Immunology, thesis “Influence of erythroblasts on reactions of humoral and cell mediated immunity”).

1988 – 2004 Worked as research fellow in RIFCI, Novosibirsk, Russia.

2002 Received a D.Sc. degree in Medical Sciences with thesis “Cytokine synthesizing activity of erythroid nucleated cells”.

2004 – present Founded and headed the Laboratory of molecular immunology in RIFCI.

2004 – 2015 Was a deputy director for scientific efforts in RIFCI, Novosibirsk, Russia.

2015 – 2018 Head of the RIFCI, Novosibirsk, Russia.

2005 Was promoted to the rank of professor in Allergology and Immunology specialty.

2018-2020 Founded and headed the Laboratory of cell technologies in Immunotherapy in Novosibirsk State University (NSU), Novosibirsk, Russia.

2018 – Present Lecturer of the Cell Technology in Immunotherapy Course in Institute of Medicine and Medical Technologies, NSU, Novosibirsk, Russia.

• Cellular Immunology
• Molecular Immunology
• Oncoimmunology
• Cytokines
• Immunoregulation
• Autoimmunity
• Inflammation
• Gene Expression

• Alshevskaya, A.; Lopatnikova, J.; Zhukova, J.; Chumasova, O.; Shkaruba, N.; Sizikov, A.; Evsegneeva, I.; Demina, D.; Nepomniashchikch, V.; Karaulov, A.; Sennikov, S. The Influence of Severity and Disease Duration on TNF Receptors’ Redistribution in Asthma and Rheumatoid Arthritis. Cells 2023, 12, 5. https://doi.org/10.3390/cells12010005
• Alsalloum, A.; Shevchenko, J.A.; Sennikov, S. The Melanoma-Associated Antigen Family A (MAGE-A): A Promising Target for Cancer Immunotherapy? Cancers 2023, 15, 1779. https://doi.org/10.3390/cancers15061779
• Nazarov, K.; Perik-Zavodskii, R.; Perik-Zavodskaia, O.; Alrhmoun, S.; Volynets, M.; Shevchenko, J.; Sennikov, S. Murine Placental Erythroid Cells are Mainly Represented by CD45+ Immunosuppressive Erythroid Cells and Secrete CXCL1, CCL2, CCL3 and CCL4 Chemokines. Int. J. Mol. Sci. 2023, 24, 8130. hĴps://doi.org/ 10.3390/ijms24098130
• Shevchenko JA, Perik-Zavodskii RY, Nazarov KV, Denisova VV, Perik-Zavodskaya OY., Philippova YG, Alsalloum A, Sennikov SV. (2023) Immunoregulatory properties of erythroid nucleated cells induced from CD34+ progenitors from bone marrow. PLoS ONE 18(6): e0287793. https://doi.org/10.1371/journal.pone.0287793
• Tereshchenko, V.; Shevyrev, D.; Fisher, M.; Bulygin, A.; Khantakova, J.; Sennikov, S. TCR Sequencing in Mouse Models of Allorecognition Unveils the Features of Directly and Indirectly Activated Clonotypes. Int. J. Mol. Sci. 2023, 24, 12075. https://doi.org/10.3390/ijms241512075
• Alsalloum, A.; Shevchenko, J.; Fisher, M.; Philippova, J.; Perik-Zavodskii, R.; Perik-Zavodskaia, O.; Alrhmoun, S.; Lopatnikova, J.; Vasily, K.; Volynets, M.; et al. Exploring TCR-like CAR-Engineered Lymphocyte Cytotoxicity against MAGE-A4. Int. J. Mol. Sci. 2023, 24, 15134. https:// doi.org/10.3390/ijms242015134
• Shevchenko, J.A.; Nazarov, K.V.; Alshevskaya, A.A.; Sennikov, S.V. Erythroid Cells as Full Participants in the Tumor Microenvironment. Int. J. Mol. Sci. 2023, 24, 15141. https://doi.org/ 10.3390/ijms242015141
• Khantakova JN and Sennikov SV (2023) T-helper cells flexibility: the possibility of reprogramming T cells fate. Front. Immunol. 14:1284178. doi: 10.3389/fimmu.2023.1284178
• Perik-Zavodskaia, O.; Perik-Zavodskii, R.; Nazarov, K.; Volynets, M.; Alrhmoun, S.; Shevchenko, J.; Sennikov, S. Murine Bone Marrow Erythroid Cells Have Two Branches of Differentiation Defined by the Presence of CD45 and a Different Immune Transcriptome Than Fetal Liver Erythroid Cells. Int. J. Mol. Sci. 2023, 24, 15752. https://doi.org/10.3390/ijms242115752
• Perik-Zavodskaia, O.; Alrhmoun, S.; Perik-Zavodskii, R.; Zhukova, J.; Lopatnikova, J.; Volynets, M.; Alshevskaya, A.; Sennikov, S. Knockouts of TNFRSF1A and TNFRSF1B Genes in K562 Cell Line Lead to Diverse Long-Lasting Responses to TNF-α. Int. J. Mol. Sci. 2023, 24, 17169. https://doi.org/ 10.3390/ijms242417169
• Philippova J, Shevchenko J, Sennikov S (2024) GD2-targeting therapy: a comparative analysis of approaches and promising directions. Front. Immunol. 15:1371345. doi: 10.3389/fimmu.2024.1371345
• Perik-Zavodskii R, Perik-Zavodskaia O, Shevchenko J, Volynets M, Alrhmoun S, Nazarov K, Denisova V, Sennikov S. (2024) A subpopulation of human bone marrow erythroid cells displays a myeloid gene expression signature similar to that of classic monocytes. PLoS ONE 19(7): e0305816. https://doi.org/10.1371/journal.pone.0305816
• Fisher MS, Kurilin VV, Bulygin AS, Shevchenko JA, Philippova JG, Taranov OS, Ivleva EK, Maksyutov AZ and Sennikov SV (2024) Dendritic cells transfected with DNA constructs encoding CCR9, IL-10, and type II collagen demonstrate induction of immunological tolerance in an arthritis model. Front. Immunol. 15:1447897. doi: 10.3389/fimmu.2024.1447897
• Perik-Zavodskii R, Perik-Zavodskaia O, Alrhmoun S, Volynets M, Shevchenko J, Nazarov K, Denisova V and Sennikov S (2024) Single-cell multi-omics reveal stage of differentiation and trajectory-dependent immunity-related gene expression patterns in human erythroid cells. Front. Immunol. 15:1431303. doi: 10.3389/fimmu.2024.1431303
• Nazarov K, Perik-Zavodskii R, Perik-Zavodskaia O, Alrhmoun S, Volynets M, Shevchenko J, Sennikov S. (2024) Acute blood loss in mice forces differentiation of both CD45-positive and CD45-negative erythroid cells and leads to a decreased CCL3 chemokine production by bone marrow erythroid cells. PLoS ONE 19(9): e0309455. https://doi.org/10.1371/journal.pone.0309455
• Alsalloum A, Shevchenko JA, Sennikov S. NY-ESO-1 antigen: A promising frontier in cancer immunotherapy. Clin Transl Med. 2024 Sep;14(9):e70020. doi: 10.1002/ctm2.70020. PMID: 39275923; PMCID: PMC11399778.
• Sennikov S, Volynets M, Alrhmoun S, Perik-Zavodskii R, Perik-Zavodskaia O, Fisher M, Lopatnikova J, Shevchenko J, Nazarov K, Philippova J, Alsalloum A, Kurilin V, Silkov A. Modified Dendritic cell-based T-cell expansion protocol and single-cell multi-omics allow for the selection of the most expanded and in vitro-effective clonotype via profiling of thousands of MAGE-A3-specific T-cells. Front Immunol. 2024 Oct 10; 15:1470130. doi: 10.3389/fimmu.2024.1470130. PMID: 39450161; PMCID: PMC11499154.
• Golikova EA, Alshevskaya AA, Alrhmoun S, Sivitskaya NA, Sennikov SV. TCR-T cell therapy: current development approaches, preclinical evaluation, and perspectives on regulatory challenges. J Transl Med. 2024 Oct 4;22(1):897. doi: 10.1186/s12967-024-05703-9. PMID: 39367419; PMCID: PMC11451006.
• Zhukova JV, Lopatnikova JA, Alshevskaya AA, Sennikov SV. Molecular mechanisms of regulation of IL-1 and its receptors. Cytokine Growth Factor Rev. 2024 Dec; 80:59-71. doi: 10.1016/j.cytogfr.2024.09.004. Epub 2024 Oct 5. PMID: 39414547.
• Alsalloum A., Alrhmoun S., Perik-Zavodskaia O., Fisher M., Volynets M., Lopatnikova J., Perik-Zavodskii R., Shevchenko J., Philippova J., Solovieva O., Zavjalov E., Kurilin V., Shiku H., Silkov A., Sennikov S. (2024) Decoding NY-ESO-1 TCR T cells: transcriptomic insights reveal dual mechanisms of tumor targeting in a melanoma murine xenograft model. Front. Immunol. 15:1507218. doi: 10.3389/fimmu.2024.1507218
• Alrhmoun S, Fisher M, Lopatnikova J, Perik-Zavodskaia O, Volynets M, Perik-Zavodskii R, Shevchenko J, Nazarov K, Philippova J, Alsalloum A, Kurilin V, Silkov A, Sennikov S. Targeting Precision in Cancer Immunotherapy: Naturally-Occurring Antigen-Specific TCR Discovery with Single-Cell Sequencing. Cancers (Basel). 2024 Nov 30;16(23):4020. doi: 10.3390/cancers16234020. PMID: 39682207; PMCID: PMC11640272.Fisher MS and Sennikov SV (2025) T-regulatory cells for the treatment of autoimmune diseases. Front. Immunol. 16:1511671. doi: 10.3389/fimmu.2025.1511671
• Alshevskaya, A.; Zhukova, J.; Lopatnikova, J.; Vasilyev, F.; Khutornoy, I.; Golikova, E.; Kireev, F.; Sennikov, S. Nonlinear Dynamics of TNFR1 and TNFR2 Expression on Immune Cells: Genetic and Age-Related Aspects of Inflamm-Aging Mechanisms. Biomedicines 2025, 13, 852. https://doi.org/10.3390/biomedicines13040852
• Kireev, F.D.; Lopatnikova, J.A.; Alshevskaya, A.A.; Sennikov, S.V. Role of Tumor Necrosis Factor in Tuberculosis. Biomolecules 2025, 15, 709. https://doi.org/10.3390/biom15050709
• Perik-Zavodskii, R.; Perik-Zavodskaia, O.; Shevchenko, J.; Nazarov, K.; Gizbrekht, A.; Alrhmoun, S.; Denisova, V.; Sennikov, S. Human and Mouse Bone Marrow CD45+ Erythroid Cells Have a Constitutive Expression of Antibacterial Immune Response Signature Genes. Biomedicines 2025, 13, 1218. https://doi.org/10.3390/biomedicines13051218
• Perik-Zavodskii R, Perik-Zavodskaia O, Alrhmoun S, Lopatnikova J, Alshevskaya A, Zhukova J, Shevchenko J, Shkaruba N, Sivitskaya N, Suleimanov S, Sheveleva E, Nazarov K, Kireev F, Sizikov A, Golikova E and Sennikov S (2025) Single-cell multi-omics reveals the TNF-a activation threshold for Classical Monocytes by studying healthy donors and rheumatoid arthritis patients. Front. Immunol. 16:1572823. doi: 10.3389/fimmu.2025.1572823
• Alshevskaya, A.; Suleimanov, S.; Sheveleva, E.; Perik-Zavodskii, R.; Perik-Zavodskaia, O.; Alrhmoun, S.; Lopatnikova, J.; Zhukova, J.; Shkaruba, N.; Sivitskaya, N.; Sizikov A.; Golikova E.; Sennikov S. Molecular Signatures of Dendritic Cell Activation upon TNF Stimulation: A Multi-Omics Study in Rheumatoid Arthritis. Int. J. Mol. Sci. 2025, 26, 6071. https://doi.org/10.3390/ijms26136071
• Perik-Zavodskii R, Perik-Zavodskaia O, Volynets M, Alrhmoun S and Sennikov S (2025) TCRscape: a single-cell multi-omic TCR profiling toolkit. Front. Bioinform. 5:1641491. doi: 10.3389/fbinf.2025.1641491
• Perik-Zavodskaia O, Perik-Zavodskii R, Alrhmoun S, Nazarov K, Shevchenko J, Zaitsev K and Sennikov S (2025) Multi-omic analysis identifies erythroid cells as the major population in mouse placentas expressing genes for antigen presentation in MHC class II, chemokines, and antibacterial immune response. Front. Immunol. 16:1644983. doi: 10.3389/fimmu.2025.1644983
• Lopatnikova JA and Sennikov SV (2025) Bispecific immunotherapy based on antibodies, T-cell receptors, and aptamers: mechanisms of action, adverse effects, and future perspectives. Front. Immunol. 16:1679092. doi: 10.3389/fimmu.2025.1679092
• Bulygin, A.; Fisher, M.; Kurilin, V.; Alrhmoun, S.; Perik-Zavodskii, R.; Perik-Zavodskaia, O.; Volynets, M.; Shkaruba, N.; Obleukhova, I.; Khantakova, J.; Golikova, E.; Silkov, A.; Sennikov, S. Assessment and Characterization of Induced Alloantigen-Specific Regulatory T Cells Obtained by the Inhibition of CDK8/19 with the AS2863619 Compound. Int. J. Mol. Sci. 2025, 26, 10957. https://doi.org/ 10.3390/ijms262210957
• Shevchenko, J.A.; Gizbrekht, A.A.; Sennikov, S.V. Chemokines in Pregnancy. Biomolecules 2025, 15, 1645. https://doi.org/10.3390/biom15121645
• Alrhmoun S, Perik-Zavodskii R, Fisher M, Lopatnikova J,Perik-Zavodskaia O, Shevchenko J, Nazarov K, Philippova J, Kurilin V, Kichakova O, Zavjalov EL, Golikova E, Timashev P, Glybochko P. and Sennikov S (2025) Anti-HER2/neu TCR-T Cells in Action: linking transcriptional signatures, secretomics, and In Vivo tumor suppression. Front. Immunol. 16:1646404. doi:10.3389/fimmu.2025.1646404
• Zhukova JV, Lopatnikova JA and Sennikov SV (2025) Structural and dynamic properties of IL1 receptors. Front. Immunol.16:1714624. doi:10.3389/fimmu.2025.1714624
• Fisher, M.; Philippova, J.; Kurilin, V.; Sennikov, S. TCR-Based Antigen-Specific Therapy for Type 1 Diabetes Mellitus: From Editing Autoreactive Clones to Tolerance Induction. Int. J. Mol. Sci. 2025, 26, 11563. hĴps://doi.org/10.3390/ijms262311563
• Bulygin, A.; Golikova, E.; Sennikov, S. Development of αβ and γδ T Cells in the Thymus and Methods of Analysis. Int. J. Mol. Sci. 2025, 26, 11939. https://doi.org/10.3390/ijms262411939
• Kurilin V, Fisher M, Obleukhova I, Sennikov S. Cellular Immunotherapies for Multiple Sclerosis: Mechanistic Insights and Clinical Advances. Int J Mol Sci. 2026 Jan 6;27(2):585. doi: 10.3390/ijms27020585. PMID: 41596238.
• Zhukova J, Lopatnikova J, Vasilyev F, Alshevskaya A, Lipa D, Sennikov S. Age- and Genotype-Associated Specific Expression of IL-1 and TNF Receptors on Immunocompetent Cells. Int J Mol Sci. 2026 Jan 13;27(2):807. doi: 10.3390/ijms27020807. PMID: 41596456.
• Savostyanova TA, Lopatnikova JA and Sennikov SV (2026) The guardian of the genome meets immunotherapy: p53-based strategies. Front. Immunol. 17:1762679. doi: 10.3389/fimmu.2026.1762679

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• https://orcid.org/0000-0002-7366-7768
• https://www.scopus.com/authid/detail.uri?authorId=7004762032
• https://www.webofscience.com/wos/author/record/O-2164-2013