Xiaona Wang Ph.D.

Associate Professor

Henan Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, China

Office Tel. +86371-85515717

E-mail: xiaonawang2015@163.com

Nationality: China

Scopus: www.scopus.com/authid/detail.uri?authorId=57214249518

EDUCATION

Doctor of Neurobiology.

Shandong University, China (Aug 2011- Jun 2016).

Supervisor: Professor Renzhi Zhan.

ACADEMIC APPOINTMENTS

Associate Professor

Supervisor of Master's Degree in Zhengzhou University, Henan Key Laboratory of Children’s Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, China (Jan 2024 - the present).

Assistant Professor

Supervisor of Master's Degree in Zhengzhou University, Henan Key Laboratory of Children’s Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, China (Aug 2020 - Dec 2023).

Assistant Professor

Henan Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, China (Aug 2017 - Jul 2020).

Postdoctoral Research Fellow

Biochemistry and Molecular Biology, Indiana University-Purdue University Indianapolis, Indianapolis (2016-2017).

RESEARCH DESCRIPTION

1. Genetic and circuit mechanisms of autism spectrum disorder, epilepsy and intellectual disability.
2. Pathophysiological mechanisms underlying neurodevelopmental disabilities.
3. Exploring neuroprotective effect of drugs against neurological disorders.

• Genetic and circuit mechanisms of autism spectrum disorder, epilepsy and intellectual disability
• Pathophysiological mechanisms underlying neurodevelopmental disabilities
• Exploring neuroprotective effect of drugs against neurological disorders

• Yaodong Zhang, Xiaotong Zhao, Chao Gao, Shengli Shi, Mengyuan Chen, Bin Guo, Shunan Hu, Daoqi Mei*, Xujun Duan*, Xiaona Wang*. Deficiency of calretinin in prefrontal cortex causes behavioral deficits relevant to autism spectrum disorder in mice. Molecular Brain. 2025, 18:61-73.
• Xiaona Wang#*, Mengyuan Chen, Daoqi Mei, Shengli Shi, Jisheng Guo, Chao Gao, Qi Wang, Shuai Zhao, Xingxue Yan, Huichun Zhang, Yanli Wang, Bin Guo*, Yaodong Zhang*. Somatostatin-expressing interneurons of prefrontal cortex modulate social deficits in the Magel2 mouse model of autism. Molecular Autism. 2025, 16(1):18-34.
• Daoqi Mei, Yu Gu, Bingbing Zhang, Shiyue Mei, Xiaona Wang, Yuanning Ma, Jie Deng, Jihong Tang. Identification of three novel GNAO1 variants in a Chinese cohort with GNAO1 encephalopathy: expanding the clinical and genetic spectrum. Orphanet journal of rare diseases. 2025, 20 (1): 440.
• Xiaona Wang#*, Yaodong Zhang, Shuying Luo, Ke Zhao, Chao Gao, Daoqi Mei, Yongtao Duan, Shunan Hu. Restoration of nNOS expression rescues autistic-like phenotypes through normalization of AMPA receptor-mediated neurotransmission. Molecular Neurobiology. 2024, 61(9):6599-6612.
• Ke Zhao, Xinkui Zhou, Mengyuan Chen, Lingshan Gou, Daoqi Mei, Chao Gao, Shuai Zhao, Shuying Luo, Xiaona Wang*, Tao Tan*, Yaodong Zhang*. Neuroprotective effects of CXCR2 antagonist SB332235 on traumatic brain injury through suppressing NLRP3 infammasome. Neurochemical Research. 2024,49:184-198.
• Jisheng Guo, Xiaona Wang, Guangming Li, Qiong Wang, Fengqin Wang, Jinjin Liu, Xu Feng, Chao Wang. Reliability of serum-derived connectome indicators in identifying cirrhosis. Journal of proteome research. 2024, 23(10):4729-4741.
• Ke Zhao, Yaodong Zhang, Xiaona Wang, Yanli Ma, Weiguang Geng, Lingshan Gou. Dravet syndrome caused by a novel nonsense mutation of SCN1A gene locus: a case report. Chinese Journal of Birth Health & Heredity. 2024, 32:1-5.
• Zhengqin Zhao, Xiaona Wang, Dong Wang, Jiahui Zhang, Hongjie Yang. Correlation between glucose metabolism and body mass index in tumor lesions of patients with lung cancer. Discover oncology. 2024,15(1):655.
• Li Wang, Zhongliang Li , Junhui Fu , Kaili Xu , Daoqi Mei , Xiaona Wang, Xilong Du, Taisong Li. Case report: second report of neuromuscular syndrome caused by biallelic variants in ASCC3. Frontiers in Genetics.2024. 15:1382275.
• Xiaona Wang#*, Zhengqin Zhao, Jisheng Guo, Daoqi Mei, Yongtao Duan, Yaodong Zhang*, Lingshan Gou*. GABAB1 receptor knockdown in prefrontal cortex induces behavioral aberrations associated with autism spectrum disorder in mice. Brain Research Bulletin. 2023, 202:110755.
• Xiaona Wang#*, Daoqi Mei#, Lingshan Gou, Shuai Zhao, Chao Gao, Jisheng Guo, Shuying Luo, Bin Guo, Zhigang Yang, Qi Wang*, Tao Tan*, Yaodong Zhang*. Functional evaluation of a novel GRIN2B missense variant associated with epilepsy and intellectual disability. Neuroscience. 2023, 526:107-120.
• Yu Gu, Daoqi Mei*, Xiaona Wang*, Ang Ma, Jinghui Kong, Yaodong Zhang*. Clinical and genetic analysis of benign familial infantile epilepsy caused by PRRT2 gene variant. Frontiers in Neurology. 2023, 14:1135044.
• Xiaona Wang#, Daoqi Mei, Shuying Luo, Chao Gao, Yaodong Zhang*. Effects of ICG-001 on autistic behaviors and the development of hippocampal dendritic spine morphology in rats. Chinese Journal of Applied Clinical Pediatrics. 2023, 38:140-145.
• Yuke Li, Xiaona Wang, Mengyuan Liu, Yang Gao, Baiyun Chen, Daoqi Mei, Huichun Zhang, Chao Gao. Clinical characteristics and genetic variant analysis of a child with Snijders Blok-Campeau syndrome. Chinese Journal of Medical Genetics. 2023, 40 (4):402-407.
• Mengyuan Liu, Bing Li, Xiaona Wang, Dongxiao Li, Zhenhua Xie, Yuke Li, Yang Gao, Baiyun Chen, Huichun Zhang, Yanli Wang, Chao Gao. A de novo low-frequency mosaic variant of KIF1A causes hereditary spastic paraplegia: a literature review. Annals of Human Genetics. 2023, 2:1-8.
• Daoqi Mei, Yu Gu, Shiyue Mei, Yongtao Duan, Xiaona Wang, Chao Gao, Qiuping He, Yaodong Zhang. A case of Poirier-Bienvenu neurodevelopmental syndrome associated with CSNK2B gene shear variation and literature review. Chinese Journal of Neurology. 2023,56:686-694.
• Chao Gao, Bernadeta Zabielska, Fuyong Jiao, Daoqi Mei, Xiaona Wang, Katarzyna Kotulska, Sergiusz Jozwiak. Subependymal giant cell astrocytomas in Tuberous Sclerosis Complex-current views on their pathogenesis and management. Journal of Clinical Medicine. 2023,12 (3): 956-970.
• Chao Gao, Mikolaj Pielas, Fuyong Jiao, Daoqi Mei, Xiaona Wang, Katarzyna Kotulska, Sergiusz Jozwiak. Epilepsy in Dravet Syndrome-current and future therapeutic opportunities. Journal of Clinical Medicine. 2023,12 (7): 2532-2543.
• Xiaona Wang#*, Zhiyue Guo, Daoqi Mei, Yaodong Zhang, Shuai Zhao, Shunan Hu, Shuying Luo, Qi Wang*, Chao Gao*. The GluN2B-Trp373 NMDA receptor variant is associated with autism-, epilepsy-related phenotypes and reduces NMDA receptor currents in rats. Neurochemical Research. 2022, 47(6):1588-1597.
• Daoqi Mei, Shiyue Mei, Xiaona Wang*, Yuan Wang, Guohong Chen, ZhixiaoYang, Xiaoyi Chen, Yaodong Zhang, Xiu-an Yang. Early-onset epileptic encephalopathy type 27 caused by missense variation of GRIN2B gene: a case report. Journal of Clinical Paediatrics. 2022, 40(4):300-305.
• Zhengqin Zhao, Min Su, Dong Wang, Jing Ye, Xiaona Wang*. Alterations of the thyroid hormone levels in children with intellectual disability. Neuropediatrics. 2022, 54(1):53-57.
• Lingshan Gou, Tianya Liu, Yi Wang, Qin Wu, Shunan Hu, Bulian Dong, Chuanxia Wang, Yan Zhang, Xinghu Shan, Xiaona Wang, Feng Suo, Maosheng Gu*. Clinical utilization of chromosomal microarray analysis for the genetic analysis in subgroups of pregnancy loss. The Journal of Maternal-Fetal & Neonatal Medicine. 2022,35 (22):4404-4411.
• Xiaona Wang#*, Chao Gao, Yaodong Zhang, Shunan Hu, Yidan Qiao, Zhengqin Zhao, Lingshan Gou, Jijun Song, Wang Qi*. Overexpression of mGluR7 in the prefrontal cortex attenuates autistic behaviors in mice. Frontiers in Cellular Neuroscience. 2021,15: 689611.
• Xiaona Wang#*, Zhigang Yang#, Shuanfeng Fang, Yaodong Zhang, Jisheng Guo, Lingshan Gou. Declining levels of specialized synaptic surface proteins in nNOS-expressing interneurons in mice treated prenatally with valproic acid. Neurochemical Research. 2021, 46 (7):1794.
• Xiaona Wang#*, Yaodong Zhang, Weyland Cheng, Yinbo Gao, Shao Li. Decreased excitatory drive onto hilar neuronal nitric oxide synthase expressing interneurons in chronic models of epilepsy. Brain Research. 2021,1764:147467.
• Daoqi Mei, Shiyue Mei*, Guohong Chen, Yuan Wang, Xiaona Wang, Jun Zhang, Xiaoyi Chen, Dongxiao Li, Yaodong Zhang. Phenotypic and genetic analysis of a case with hypohidrotic ectodermal dysplasia due to Xq13.1 microdeletion. Chinese Journal of Medical Genetics. 2021, 38(3):219-223.
• Daoqi Mei, Shiyue Mei*, Yuan Wang, Zhihui Tang, Xiaoyi Chen, Guohong Chen, Yaodong Zhang, Xiaona Wang. Clinical characteristics and genetic analysis of early epileptic encephalopathy caused by YWHAG gene mutation. Chinese Journal of Neurology. 2021, 54(1):16-21.
• Daoqi Mei, Guohong Chen, Yuan Wang, Shiyue Mei*, Zhihui Tang, Junfang Suo, Xiaona Wang, Yaodong Zhang, Shijie Dong, Xinzheng Hao, Xiu-an Yang. Clinical features and gene mutation analysis of CDKL5 gene related early-onset epileptic encephalopathy. Chinese Journal of Neurology. 2021, 54(4):320-328.
• Xiaona Wang#*, Chao Gao, Yaodong Zhang, Jinxiu Xu, Quanfeng Fang, Lingshan Gou, Zhigang Yang, Daoqi Mei, Leiming Liu, Linfei Li, Jing Liu, Huichun Zhang, Yinsen Song*. Neuronal nitric oxide synthase knockdown within basolateral amygdala induces autistic-related phenotypes and decreases excitatory synaptic transmission in mice. Frontiers in Neuroscience. 2020, 14: 886.
• Daoqi Mei, Shiyue Mei*, Xiaona Wang, Xiaoyi Chen, Yuan Wang, Guohong Chen, Yaodong Zhang,Ying Wang, Shijie Dong. Clinical phenotype and genetic characteristics of two families with tuberous sclerosis. Chinese Journal of Medical Genetics. 2020,19(10):1040-1043.
• Chao Gao, Xiaona Wang, Shiyue Mei, Dongxiao Li, Jiali Duan, Pei Zhang, Baiyun Chen, Liang Han, Yang Gao, Zhenhua Yang, Bing Li, Xiu-an Yang*. Diagnostic yields of Trio-WES accompanied by CNVseq for rare neurodevelopmental disorders. Frontiers in Genetics. 2019,10: 485.
• Xiaona Wang#, Jisheng Guo, Yinsen Song, Qi Wang, Shunan Hu, Lingshan Gou, Yinbo Gao*. Decreased number and expression of nNOS-positive interneurons in basolateral amygdala in two mouse models of autism. Frontiers in Cellular Neuroscience. 2018, 12: 251.
• Xiaona Wang#, Jing Tao, Yidan Qiao, Shuying Luo, Zhenqin Zhao, Yinbo Gao, Jisheng Guo, Jinghui Kong, Chongfen Chen, Lili Ge, Bo Zhang, Pengbo Guo, Lei Liu, Yinsen Song*. Gastrodin rescues autistic-like phenotypes in valproic acid-induced animal model. Frontiers in Neurology. 2018, 9: 1052.
• Xiaona Wang#, Chunhua Liu, Xiaochen Wang, Fei Gao, Renzhi Zhan*. Density and neurochemical profiles of neuronal nitric oxide synthase-expressing interneuron in the mouse basolateral amygdala. Brain Research. 2017, 1663: 106-113.
• Yang Jin, Jian Peng, Xiaona Wang, Dong Zhang, Tianyin Wang*. Ameliorative effect of Ginsenoside Rg1 on lipopolysaccharide-induced cognitive impairment: role of cholinergic system. Neurochemical Research. 2017, 42 (5):1299-1307.
• Xiaona Wang#, Peng Li, Jingsheng Liu, Xunbo Jin, Lianjun Li, Dong Zhang, Peng Sun*. Gastrodin attenuates cognitive deficits induced by 3,3′-iminodipropionitrile. Neurochemical Research. 2016, 41: 1401-1409.
• Xiaona Wang#, Tan Yuan, Feng Zhang*. Ameliorative effect of gastrodin on 3,3'- iminodipropionitrile-induced memory impairment in rats. Neuroscience Letters. 2015, 594: 40-45.
• Xiaona Wang#, Shaofeng Yan, Aiqin Wang, Yanli Li, Feng Zhang*. Gastrodin ameliorates memory deficits in 3,3'-iminodipropionitrile-induced rats: possible involvement of dopaminergic system. Neurochemical Research. 2014, 39:1458-1466.
• Zhaoliang Liang, Lin Zhang, Xiaochen Wang, Fei Gao, Xiaona Wang, Shuo Zhou, Shuyan Yu, Renzhi Zhan*. Distribution and neurochemical features of neuronal nitric oxide synthase-expressing interneurons in the rat dentate gyrus. Brain Research. 2013, 1505:11-21.

• Neuroscience. Xiamen University Press. ISBN-978-7-5615-9710-1. 2025, Co-author

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